Compound Cis-Regulatory Elements With Both Boundary and Enhancer Sequences in the Human Genome

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dc.contributor.authorJjingo, Daudi
dc.contributor.authorWang, Jianrong
dc.contributor.authorConley, Andrew B.
dc.contributor.authorLunyak, Victoria V.
dc.contributor.authorJordan, I. King
dc.date.accessioned2018-12-18T13:36:35Z
dc.date.accessioned2021-12-21T08:58:55Z
dc.date.available2018-12-18T13:36:35Z
dc.date.available2021-12-21T08:58:55Z
dc.date.issued2013-10
dc.description.abstractMotivation: It has been suggested that presumably distinct classes of genomic regulatory elements may actually share common sets of features and mechanisms. However, there has been no genome-wide assessment of the prevalence of this phenomenon. Results: To evaluate this possibility, we performed a bioinformatics screen for the existence of compound regulatory elements in the human genome. We identified numerous such collocated boundary and enhancer elements from human CD4รพ T cells. We report evidence that such compound regulatory elements possess unique chromatin features and facilitate cell type-specific functions related to inflammation and immune response in CD4+ T cells.en_US
dc.identifier.citationJjingo et al, Bioinformatics, Volume 29, Issue 24, 15 December 2013, Pages 3109โ€“3112, https://doi.org/10.1093/bioinformatics/btt542en_US
dc.identifier.issn1460-2059
dc.identifier.urihttps://hdl.handle.net/20.500.11951/688
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.subjectCompound regulatory elements (Genome)en_US
dc.titleCompound Cis-Regulatory Elements With Both Boundary and Enhancer Sequences in the Human Genomeen_US
dc.typeArticleen_US
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