Compound Cis-Regulatory Elements With Both Boundary and Enhancer Sequences in the Human Genome
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Date
2013-10
Journal Title
Journal ISSN
Volume Title
Publisher
Oxford University Press
Abstract
Motivation: It has been suggested that presumably distinct classes of genomic regulatory elements may actually share common sets of features and mechanisms. However, there has been no genome-wide assessment of the prevalence of this phenomenon.
Results: To evaluate this possibility, we performed a bioinformatics screen for the existence of compound regulatory elements in the human genome. We identified numerous such collocated boundary and enhancer elements from human CD4รพ T cells. We report evidence that such compound regulatory elements possess unique chromatin features and facilitate cell type-specific functions related to inflammation and immune response in CD4+ T cells.
Description
Keywords
Compound regulatory elements (Genome)
Citation
Jjingo et al, Bioinformatics, Volume 29, Issue 24, 15 December 2013, Pages 3109โ3112, https://doi.org/10.1093/bioinformatics/btt542