Feasibility, Reliability and Validity of Health-Related Quality of Life Questionnaire Among Adult Pulmonary Tuberculosis Patients in Urban Uganda: Cross-Sectional Study

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dc.contributor.authorBabikako, Harriet M
dc.contributor.authorNeuhauser, Duncan
dc.contributor.authorKatamba, Achilles
dc.contributor.authorMupere, Ezekiel
dc.date.accessioned2018-12-17T13:47:29Z
dc.date.available2018-12-17T13:47:29Z
dc.date.issued2010-09
dc.descriptionThe study provides evidence that the MOS instrument is valid, and reliably measures HRQoL among TB patients, and can be used in a wide variety of study populations. The HRQoL differed by hospital settings, by duration of TB therapy, and by gender in older age groups.en_US
dc.description.abstractBackground Despite the availability of standard instruments for evaluating health-related quality life (HRQoL), the feasibility, reliability, and validity of such instruments among tuberculosis (TB) patients in different populations of sub-Saharan Africa where TB burden is of concern, is still lacking. Objective We established the feasibility, reliability, and validity of the Medical Outcomes Survey (MOS) in assessing HRQoL among patients with pulmonary tuberculosis in Kampala, Uganda. Methods In a cross-sectional study, 133 patients with known HIV status and confirmed pulmonary TB disease were recruited from one public and one private hospital. Participants were enrolled based on duration of TB treatment according to the following categories: starting therapy, two months of therapy, and eight completed months of therapy. A translated and culturally adapted standardized 35-item MOS instrument was administered by trained interviewers. The visual analogue scale (VAS) was used to cross-validate the MOS. Results The MOS instrument was highly acceptable and easily administered. All subscales of the MOS demonstrated acceptable internal consistency with Cronbach's alpha above 0.70 except for role function that had 0.65. Each dimension of the MOS was highly correlated with the dimension measured concurrently using the VAS providing evidence of validity. Construct validity demonstrated remarkable differences in the functioning status and well-being among TB patients at different stages of treatment, between patients attending public and private hospitals, and between men and women of older age. Patients who were enrolled from public hospital had significantly lower HRQoL scores (0.78 (95% confidence interval (CI); 0.64-0.95)) for perceived health but significantly higher HRQoL scores (1.15 (95% CI; 1.06-1.26)) for health distress relative to patients from private hospital. Patients who completed an 8 months course of TB therapy had significantly higher HRQoL scores for perceived health (1.93 (95% CI; 1.19-3.13)), health distress subscales (1.29 (95% CI; 1.04-1.59)) and mental health summary scores (1.27 (95% CI; 1.09-1.48)) relative to patients that were starting therapy in multivariable analysis. Completion of 8 months TB therapy among patients who were recruited from the public hospital was associated with a significant increase in HRQoL scores for quality of life subscale (1.26 (95% CI; 1.08-1.49)), physical health summary score (1.22 995% CI; 1.04-1.43)), and VAS (1.08 (95% CI; 1.01-1.15)) relative to patients who were recruited from the private hospital. Older men were significantly associated with lower HRQoL scores for physical health summary score (0.68 (95% CI; 0.49-0.95)) and VAS (0.87 (95% CI; 0.75-0.99)) relative to women of the same age group. No differences were seen between HIV positive and HIV negative patients. Conclusion The study provides evidence that the MOS instrument is valid, and reliably measures HRQoL among TB patients, and can be used in a wide variety of study populations. The HRQoL differed by hospital settings, by duration of TB therapy, and by gender in older age groups.en_US
dc.identifier.citationBabikako, Harriet M, Neuhauser, Duncan, Katamba, Achilles, Mupere, Ezekiel, 2010. Feasibility, reliability and validity of health-related quality of life questionnaire among adult pulmonary tuberculosis patients in urban Uganda: cross-sectional study, Health and Quality of Life Outcomes, 8:93; https://doi.org/10.1186/1477-7525-8-93en_US
dc.identifier.issn1477-7525
dc.identifier.urihttps://hdl.handle.net/20.500.11951/636
dc.language.isoenen_US
dc.publisherHealth and Quality of Life Outcomesen_US
dc.subjectVisual Analogue Scaleen_US
dc.subjectPrivate Hospitalen_US
dc.subjectHRQoL Scoreen_US
dc.subjectHealth Distressen_US
dc.subjectMental Health Summary Scoreen_US
dc.titleFeasibility, Reliability and Validity of Health-Related Quality of Life Questionnaire Among Adult Pulmonary Tuberculosis Patients in Urban Uganda: Cross-Sectional Studyen_US
dc.typeArticleen_US
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