Clinical and epidemiological characteristics of individuals resistant to M. tuberculosis infection in a longitudinal TB household contact study in Kampala, Uganda

Simple item page
dc.contributor.authorMa, Ningning
dc.contributor.authorZalwango, Sarah
dc.contributor.authorMalone, LaShaunda L
dc.contributor.authorNsereko, Mary
dc.contributor.authorWampande, Eddie M
dc.contributor.authorThiel, Bonnie A
dc.contributor.authorOkware, Brenda
dc.contributor.authorIgo, Robert P
dc.contributor.authorJoloba, Moses L
dc.contributor.authorMupere, Ezekiel
dc.contributor.authorMayanja-Kizza, Harriet
dc.contributor.authorBoom, W Henry
dc.contributor.authorStein, Catherine M
dc.date.accessioned2018-12-18T06:40:00Z
dc.date.available2018-12-18T06:40:00Z
dc.date.issued2014-06
dc.descriptionhis is the first study to rigorously characterize the epidemiologic risk profile of individuals with persistently negative TSTs despite close exposure to a person with TB. Additional studies are needed to characterize possible epidemiologic and host factors associated with this phenotype.en_US
dc.description.abstractBackground Despite sustained exposure to a person with pulmonary tuberculosis (TB), some M. tuberculosis (Mtb) exposed individuals maintain a negative tuberculin skin test (TST). Our objective was to characterize these persistently negative TST (PTST-) individuals and compare them to TST converters (TSTC) and individuals who are TST positive at study enrollment. Methods During a TB household contact study in Kampala, Uganda, PTST-, TSTC, and TST + individuals were identified. PTST- individuals maintained a negative TST over a 2 year observation period despite prolonged exposure to an infectious tuberculosis (TB) case. Epidemiological and clinical characteristics were compared, a risk score developed by another group to capture risk for Mtb infection was computed, and an ordinal regression was performed. Results When analyzed independently, epidemiological risk factors increased in prevalence from PTST- to TSTC to TST+. An ordinal regression model suggested age (p < 0.01), number of windows (p < 0.01) and people (p = 0.07) in the home, and sleeping in the same room (p < 0.01) were associated with PTST- and TSTC. As these factors do not exist in isolation, we examined a risk score, which reflects an accumulation of risk factors. This compound exposure score did not differ significantly between PTST-, TSTC, and TST+, except for the 5–15 age group (p = 0.009). Conclusions Though many individual factors differed across all three groups, an exposure risk score reflecting a collection of risk factors did not differ for PTST-, TSTC and TST + young children and adults. This is the first study to rigorously characterize the epidemiologic risk profile of individuals with persistently negative TSTs despite close exposure to a person with TB. Additional studies are needed to characterize possible epidemiologic and host factors associated with this phenotype.en_US
dc.identifier.citationMa, Ningning, Zalwango, Sarah, Malone, LaShaunda L, Nsereko, Mary, Wampande, Eddie M, Thiel, Bonnie A, Okware, Brenda, Igo, Robert P, Joloba, Moses L, Mupere, Ezekiel, Mayanja-Kizza, Harriet, Boom, W Henry, Stein, Catherine M, 2014. Clinical and epidemiological characteristics of individuals resistant to M. tuberculosis infection in a longitudinal TB household contact study in Kampala, Uganda, BMC Infectious Diseases, 14:352; https://doi.org/10.1186/1471-2334-14-352en_US
dc.identifier.issn1471-2334
dc.identifier.urihttps://hdl.handle.net/20.500.11951/650
dc.language.isoenen_US
dc.publisherBMC Infectious Diseasesen_US
dc.subjectTransmission risk factorsen_US
dc.subjectLatent Mtb infectionen_US
dc.subjectExposureen_US
dc.subjectHousehold characteristicsen_US
dc.subjectPPD testen_US
dc.titleClinical and epidemiological characteristics of individuals resistant to M. tuberculosis infection in a longitudinal TB household contact study in Kampala, Ugandaen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Ma_et al._Clinical and epidemiological characteristics_2014.pdf
Size:
277.52 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
UCU School of Medicine