Engineered Food Supplement Excipients From Bitter Cassava for Minimisation of Cassava Processing Waste in Environment

dc.contributor.authorTumwesigye, Kashub Steven
dc.contributor.authorO’Brien, E.
dc.contributor.authorOliveira, J.C.
dc.contributor.authorCrean, A.
dc.contributor.authorSousa-Gallagher, Maria Jose
dc.date.accessioned2022-05-11T13:10:49Z
dc.date.available2022-05-11T13:10:49Z
dc.date.issued2020
dc.descriptionThis is a research paper unchecked large-scale rudimentary upstream (submerged and solid-state fermentation processes of bitter cassava roots into alcohol have often contributed significantly to agricultural wastes in the environment.en_US
dc.description.abstractUnchecked large-scale rudimentary upstream (sub-merged and solid state) fermentation processes of bitter cas- sava roots into alcohol have often contributed significantly to agricultural wastes into environment. Thus, the study explored a proven valorisation methodology, Simultaneous Release Recovery Cyanogenesis (SRRC) along with intact bitter cassava polysaccharide-rich derivatives (CWF), as an apt to find alternative materials for food supplement excipients. Triplicate CWF powder, peeled or intact bitter cassava roots, were produced and analysed to determine crit- ical properties suitable in tablet making. Exclusion approach, using SRRC and compaction, was performed to select desired powder properties for tablet formulation. Microcrystalline cellulose, with known properties for developing drug excipients, was used as a validation reference material. Tablets, for disintegration time and in- vitro dissolution rates studies were produced using wet-granulation, and their potential to release and bio-avail Iron-Zinc investigated in-vitro (pHs 1.2 and 6.8 solutions, 37 0 C). Morphology and Iron-Zinc dissolution-release mechanisms were examined. Kinetic models were used to describe matrix dissolution and Iron-Zinc release mech- anisms. Intact root powder compaction capacity, depicted by hardness, was 4.3, 4.4 and 4.6 KG at 200, 500 and 700 MPa respectively. Scanning Electron Microscopy (SEM) showed Iron-Zinc inclusion altered tablet morphol- ogy. Efficient matrix dissolution and Iron and Zinc release were achieved, showing apex recovery efficiency (98%, 30–45 min). Fitted models well-explained dissolution and release mechanisms (mean R 2 = 0.95), demonstrating adequacy. SRRC-improved intact bitter cassava was confirmed as potential alternative excipient’s matrix for Iron and Zinc release and bioavailability. Thus, this approach is practical for indirect waste elimination, and can promote strategy for sustainable valorisation of agricultural wastes and alternative functional food supplements delivery system.en_US
dc.identifier.citationTumwesigye, Kashub Steven et al. Engineered food supplement excipients from bitter cassava for minimisation of cassava processing waste in the environment. Future Foods 1–2 (2020)en_US
dc.identifier.urihttps://hdl.handle.net/20.500.11951/978
dc.language.isoenen_US
dc.publisherFuture Foods Journalen_US
dc.subjectBitter cassavaen_US
dc.subjectValorisationen_US
dc.subjectTablets Iron-Zincen_US
dc.titleEngineered Food Supplement Excipients From Bitter Cassava for Minimisation of Cassava Processing Waste in Environmenten_US
dc.typeArticleen_US

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