Setting up a Standardized Peripheral Blood Mononuclear Cells Processing Laboratory to Support Multi-center HIV/AIDS Vaccine and Intervention Trials.

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dc.contributor.authorNjai, Harr Freeya
dc.contributor.authorGombe, Ben
dc.contributor.authorKhamis, Tomusange
dc.contributor.authorBirungi, Josephine
dc.contributor.authorRuzagira, Eugene
dc.contributor.authorAdmassu, Dareskedar
dc.contributor.authorTarragona-Fiol, Tony
dc.contributor.authorPorter, Kholoud
dc.contributor.authorStevens, Gwynneth
dc.contributor.authorMugisha, Joseph
dc.contributor.authorGilmour, Jill
dc.contributor.authorKamali, Anatoli
dc.contributor.authorKaleebu, Pontiano
dc.date.accessioned2018-08-06T12:33:46Z
dc.date.available2018-08-06T12:33:46Z
dc.date.issued2011
dc.descriptionThe aim of this study was to assess the infrastructure and capacity challenges in Africa, however significant development has been made in the number of laboratories supporting immunological and safety studies required for large-scale HIV/AIDS vaccine or intervention trials.en_US
dc.description.abstractDespite infrastructure and capacity challenges in Africa, significant development has been made in the number of laboratories supporting immunological and safety studies required for large-scale HIV/AIDS vaccine or intervention trials. In Uganda, cohorts participating in HIV intervention trials are often recruited from rural areas. To avoid transporting samples from intervention trial areas over long distances (120 km) to central laboratories in Entebbe, we set up a standardized peripheral blood mononuclear cells (PBMCs) processing laboratory at a field station in Masaka, southwest Uganda. The laboratory was well equipped and enrolled into the International AIDS Vaccine Initiative (IAVI) Quality Assurance (QA) program. Staff was trained in laboratory techniques and Good Clinical Laboratory Practice (GCLP). The laboratory received IAVI and GCLP accreditation in 2008. In this paper we describe the process and achievements of measures taken to overcome challenges, to build staff capacity, and to optimize the quality of the cells yielded.en_US
dc.identifier.citationNjai et al. Setting up a Standardized Peripheral Blood Mononuclear Cells Processing Laboratory to Support Multi-center HIV/AIDS Vaccine and Intervention Trials. Labmedicine. Vol. 42 No. 12 (December 2011)en_US
dc.identifier.urihttps://hdl.handle.net/20.500.11951/338
dc.language.isoenen_US
dc.publisherLabmedicineen_US
dc.subjectClinical Laboratoryen_US
dc.subjectClinical Laboratory - Rural Africaen_US
dc.subjectHIV/AIDS vaccineen_US
dc.titleSetting up a Standardized Peripheral Blood Mononuclear Cells Processing Laboratory to Support Multi-center HIV/AIDS Vaccine and Intervention Trials.en_US
dc.typeArticleen_US
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