Male Gender and Duration of Anti-tuberculosis Treatment Are Associated With Hypocholesterolemia in Adult Pulmonary Tuberculosis Patients in Kampala, Uganda

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dc.contributor.authorMukisa, John
dc.contributor.authorKawooya, Ismael
dc.contributor.authorNangendo, Joan
dc.contributor.authorNalutaaya, Annet
dc.contributor.authorNyamwiza, Jean
dc.contributor.authorSam, Ali
dc.contributor.authorSsenyonga, Ronald
dc.contributor.authorWorodria, William
dc.contributor.authorMupere, Ezekiel
dc.date.accessioned2018-12-18T09:57:11Z
dc.date.available2018-12-18T09:57:11Z
dc.date.issued2018-09
dc.descriptionPatients with Pulmonary tuberculosis (PTB) and hypocholesterolemia have an altered immune function, delayed sputum conversion at two months and increased mortality. However, the assessment for dyslipidemias is not often done in our setting.en_US
dc.description.abstractBackground: Patients with Pulmonary tuberculosis (PTB) and hypocholesterolemia have an altered immune function, delayed sputum conversion at two months and increased mortality. However, the assessment for dyslipidemias is not often done in our setting. Methods: A cross-sectional study was conducted among adults at an urban TB clinic in Kampala, Uganda. We included different participants at diagnosis (0), 2, 5, 6 and 8 months of anti-TB treatment. Data was collected from a complete physical examination, a pre-tested structured questionnaire, six-hour fasting lipid profiles and random blood glucose levels. Results: Of the 323 included participants, 63.5% (205/323) were males and the median age was 30 years, IQR (23-39). The prevalence of hypocholesterolemia was 43.65% (95% CI 38.3-49.2). The participants at diagnosis had the highest hypocholesterolemia prevalence, 57.3%, 95% CI (46.7-67.2); and lowest amongst those completing treatment at 6/8 months, 32.2%, 95% CI (21.6-45.2). Significant factors associated with hypocholesterolemia were: male gender (PR 1.52, 95% CI: 1.13-2.03), and duration of anti-TB treatment (0.88, 95% CI: 0.80-0.98). Conclusion: Hypocholesterolemia is common among patients with PTB. The risk of hypocholesterolemia increases with being male and reduces with increased duration of treatment. There is a need for further research in lipid abnormalities in TB patients.en_US
dc.identifier.citationMukisa, John, Kawooya, Ismael, Nangendo, Joan, Nalutaaya, Annet, Nyamwiza, Jean, Sam, Ali, Ssenyonga, Ronald, Worodria, William, Mupere, Ezekiel, 2018. Male gender and duration of anti-tuberculosis treatment are associated with hypocholesterolemia in adult pulmonary tuberculosis patients in Kampala, Uganda, African Health Sciences, Vol 18 Issue 3; DOI: https://dx.doi.org/10.4314/ahs.v18i3.3en_US
dc.identifier.urihttps://hdl.handle.net/20.500.11951/671
dc.language.isoenen_US
dc.publisherAfrican Health Sciencesen_US
dc.subjectHypocholesterolemiaen_US
dc.subjectPulmonary tuberculosisen_US
dc.subjectDuration of anti-tuberculosis treatmenten_US
dc.subjectGenderen_US
dc.titleMale Gender and Duration of Anti-tuberculosis Treatment Are Associated With Hypocholesterolemia in Adult Pulmonary Tuberculosis Patients in Kampala, Ugandaen_US
dc.typeArticleen_US
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