Changes in Whole-Blood PUFA and Their Predictors During Recovery From Severe Acute Malnutrition

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dc.contributor.authorBabirekere-Iriso, Esther
dc.contributor.authorMortensen, Charlotte G.
dc.contributor.authorMupere, Ezekiel
dc.contributor.authorRytter, Maren J. H.
dc.contributor.authorNamusoke, Hanifa
dc.contributor.authorMichaelsen, Kim F.
dc.contributor.authorBriend, André
dc.contributor.authorStark, Ken D.
dc.contributor.authorFriis, Henrik
dc.contributor.authorLauritzen, Lotte
dc.date.accessioned2018-12-17T10:44:06Z
dc.date.available2018-12-17T10:44:06Z
dc.date.issued2016-05
dc.descriptionThis prospective study took place in a paediatric nutrition rehabilitation unit in Kampala, Uganda, and assessed whole-blood fatty acid composition of children with SAM at admission, transition, discharge and follow-up (8 and 16 weeks). ANCOVA was used to identify predictors of change in whole-blood PUFA.en_US
dc.description.abstractChildren with severe acute malnutrition (SAM) with complications require in-patient management including therapeutic feeding. Little attention has been given to the effects of these feeds on the essential fatty acid status of children with SAM. The objective of this study was to describe changes in the PUFA composition in whole blood in children with SAM during treatment and to determine predictors of change. This prospective study took place in a paediatric nutrition rehabilitation unit in Kampala, Uganda, and assessed whole-blood fatty acid composition of children with SAM at admission, transition, discharge and follow-up (8 and 16 weeks). ANCOVA was used to identify predictors of change in whole-blood PUFA. The study included 120 children with SAM and twenty-nine healthy control children of similar age and sex. Among the SAM children, 38 % were female and 64 % had oedema. Whole-blood n-6 PUFA proportions increased from admission to follow-up, except for arachidonic acid, which decreased by 0·79 (95 % CI 0·46, 1·12) fatty acid percentage (FA%) from admission to transition and 0·10 (95 % CI 0·23, 0·44) FA% at discharge. n-3 Long-chain (LC) PUFA decreased by 0·21 (95 % CI 0·03, 0·40) FA% at discharge and 0·22 (95 % CI 0·01, 0·42) FA% at 8 weeks of follow-up. This decrease was greater in children from families with recent fish intake and those with nasogastric tube feeding. Current therapeutic feeds do not correct whole-blood levels of LCPUFA, particularly n-3 LCPUFA, in children with SAM. Increased attention is needed to the contents of n-3 LCPUFA in therapeutic feeds.en_US
dc.identifier.citationBabirekere-Iriso, E., Mortensen, C., Mupere, E., Rytter, M., Namusoke, H., Michaelsen, K., . . . Lauritzen, L. (2016). Changes in whole-blood PUFA and their predictors during recovery from severe acute malnutrition. British Journal of Nutrition, 115(10), 1730-1739. doi:10.1017/S0007114516000817en_US
dc.identifier.urihttps://hdl.handle.net/20.500.11951/619
dc.language.isoenen_US
dc.publisherBritish Journal of Nutritionen_US
dc.subjectSevere acute malnutritionen_US
dc.subjectWhole-blood PUFAen_US
dc.titleChanges in Whole-Blood PUFA and Their Predictors During Recovery From Severe Acute Malnutritionen_US
dc.typeArticleen_US
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