The Household Contact Study Design for Genetic Epidemiological Studies of Infectious Diseases

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dc.contributor.authorStein, Catherine M.
dc.contributor.authorHall, Noémi B.
dc.contributor.authorMalone, LaShaundaL.
dc.contributor.authorMupere, Ezekiel
dc.date.accessioned2018-12-18T07:28:44Z
dc.date.available2018-12-18T07:28:44Z
dc.date.issued2013-04
dc.descriptionMost genetic epidemiological study designs fall into one of two categories: family based and population-based (case–control). However, recent advances in statistical genetics call for study designs that combine these two approaches. We describe the household contact study design as we have applied it in our several years of study of the epidemiology of tuberculosis.en_US
dc.description.abstractMost genetic epidemiological study designs fall into one of two categories: family based and population-based (case–control). However, recent advances in statistical genetics call for study designs that combine these two approaches. We describe the household contact study design as we have applied it in our several years of study of the epidemiology of tuberculosis. Though we highlight its applicability for genetic epidemiological studies of infectious diseases, there are many facets of this design that are appealing for modern genetic studies, including the simultaneous enrollment of related and unrelated individuals, closely and distantly related individuals, collection of extensive epidemiologic and phenotypic data, and evaluation of effects of shared environment and gene by environment interaction. These study design characteristics are particularly appealing for current sequencing studies.en_US
dc.identifier.citationStein, Catherine M., Hall, Noémi B., Malone, LaShaundaL., Mupere, Ezekiel, 2013. Thehouseholdcontactstudydesignforgeneticepidemiologicalstudiesofinfectiousdiseases, 4: 61; doi: 10.3389/fgene.2013.00061en_US
dc.identifier.urihttps://hdl.handle.net/20.500.11951/657
dc.language.isoenen_US
dc.publisherApplied genetic epidemiologyen_US
dc.subjectExtended pedigreesen_US
dc.subjectGenetic associationen_US
dc.subjectWhole genome studiesen_US
dc.subjectCohort studyen_US
dc.subjectCase-contacten_US
dc.titleThe Household Contact Study Design for Genetic Epidemiological Studies of Infectious Diseasesen_US
dc.typeArticleen_US
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