Real-Time Molecular Monitoring of Chemical Environment in Obligate Anaerobes during Oxygen Adaptive Response

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dc.contributor.authorHolman, Hoi-Ying N.
dc.contributor.authorWozei, Eleanor
dc.contributor.authorLin, Zhang
dc.contributor.authorComolli, Luis R.
dc.contributor.authorBall, David. A.
dc.contributor.authorBorglin, Sharon
dc.contributor.authorFields, Matthew W.
dc.contributor.authorHazen, Terry C.
dc.contributor.authorDowning, Kenneth H.
dc.date.accessioned2018-08-15T10:45:55Z
dc.date.accessioned2021-12-21T09:36:03Z
dc.date.available2018-08-15T10:45:55Z
dc.date.available2021-12-21T09:36:03Z
dc.date.issued2009-08-26
dc.descriptionThis was a project, was determining the transient chemical properties of the intracellular environment can elucidate the paths through which a biological system adapts to changes in its environment.en_US
dc.description.abstractDetermining the transient chemical properties of the intracellular environment can elucidate the paths through which a biological system adapts to changes in its environment, for example, the mechanisms which enable some obligate anaerobic bacteria to survive a sudden exposure to oxygen. Here we used high-resolution Fourier Transform Infrared (FTIR) spectromicroscopy to continuously follow cellular chemistry within living obligate anaerobes by monitoring hydrogen bonding in their cellular water. We observed a sequence of well-orchestrated molecular events that correspond to changes in cellular processes in those cells that survive, but only accumulation of radicals in those that do not. We thereby can interpret the adaptive response in terms of transient intracellular chemistry and link it to oxygen stress and survival. This ability to monitor chemical changes at the molecular level can yield important insights into a wide range of adaptive responses.en_US
dc.identifier.citationHolman et al. Real-Time Molecular Monitoring of Chemical Environment in Obligate Anaerobes during Oxygen Adaptive Response. Lawrence Berkeley National Laboratory. California Digital Library, University of California. (26/08/ 2009)en_US
dc.identifier.urihttps://hdl.handle.net/20.500.11951/359
dc.language.isoenen_US
dc.publisherCalifornia Digital Library, University of Californiaen_US
dc.subjectChemical Environmenten_US
dc.subjectSpectromicroscopyen_US
dc.subjectAnaerobesen_US
dc.titleReal-Time Molecular Monitoring of Chemical Environment in Obligate Anaerobes during Oxygen Adaptive Responseen_US
dc.typeArticleen_US
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