Short Communication HIV Type 1 Transmitted Drug Resistance and Evidence of Transmission Clusters among Recently Infected Antiretroviral-Naive Individuals from Ugandan Fishing Communities of Lake Victoria

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dc.contributor.authorNazziwa, Jamirah
dc.contributor.authorNjai, Harr Freeya
dc.contributor.authorNdembi, Nicaise
dc.contributor.authorBirungi, Josephine
dc.contributor.authorLyagoba, Fred
dc.contributor.authorGershim, Asiki
dc.contributor.authorNakiyingi-Miiro, Jessica
dc.contributor.authorNielsen, Leslie
dc.contributor.authorMpendo, Juliet
dc.contributor.authorNanvubya, Annet
dc.contributor.authorDebont, Jan
dc.contributor.authorGrosskurth, Heiner
dc.contributor.authorKamali, Anatoli
dc.contributor.authorSeeley, Janet
dc.contributor.authorKaleebu, Pontiano
dc.date.accessioned2018-08-06T12:52:24Z
dc.date.available2018-08-06T12:52:24Z
dc.date.issued2013
dc.descriptionThe aim of this study was to assess the Human immunodeficiency virus type 1 (HIV-1) prevalence and incidence in the fishing communities on Lake Victoria in Uganda which are high.en_US
dc.description.abstractHuman immunodeficiency virus type 1 (HIV-1) prevalence and incidence in the fishing communities on Lake Victoria in Uganda are high. This population may play a role in driving the HIV epidemic in Uganda including the spread of transmitted drug resistance (TDR). We report data on TDR in this population among antiretroviral (ARV)-naive, recently infected individuals about 5 years after ARV scaling-up in Uganda. We identified phylogenetic transmission clusters and combined these with volunteer life histories in order to understand the sexual networks within this population. From a prospective cohort of 1,000 HIV-negative individuals recruited from five communities, 51 seroconverters were identified over a period of 2 years. From these, whole blood was collected and population sequencing of the HIV-1 pol gene (protease/reverse transcriptase) was performed from plasma. Drug resistance mutations (DRMs) were scored using the 2009 WHO list for surveillance of TDR. TDR prevalence categories were estimated using the WHO recommended truncated sampling technique for the surveillance of TDR for use in resource-limited settings (RLS). Of the samples 92% (47/51) were successfully genotyped. HIV-1 subtype frequencies were 15/47 (32%) A1, 20/47 (43%) D, 1/47 (2%) C, 1/47 (2%) G, and 10/ 47 (21%) unique recombinant forms. Nonnucleoside reverse transcriptase inhibitor (NNRTI) drug resistance mutation K103N was identified in two individuals and V106A in one (6%) suggesting that the level of TDR was moderate in this population. No nucleoside/tide reverse transcriptase inhibitor (NRTI) or protease inhibitor (PI) DRMs were detected. In this study, we identified five transmission clusters supported by high bootstrap values and low genetic distances. Of these, one pair included the two individuals with K103N. Two of the genotypic clusters corresponded with reported sexual partnerships as detected through prior in-depth interviews. The level of TDR to NNRTIs in these ARV-naive individuals was moderate by WHO threshold survey categorization. The transmission clusters suggest a high degree of sexual partner mixing between members of these communities.en_US
dc.identifier.citationNazziwa et al. Short Communication HIV Type 1 Transmitted Drug Resistance and Evidence of Transmission Clusters among Recently Infected Antiretroviral-Naive Individuals from Ugandan Fishing Communities of Lake Victoria. Aids Research and Human Retroviruses. Vol. 29 No. 5 (2013) Mary Ann Liebert, Inc. DOI: 10.1089/aid.2012.0123en_US
dc.identifier.urihttps://hdl.handle.net/20.500.11951/340
dc.language.isoenen_US
dc.publisherAids Research and Human Retrovirusesen_US
dc.subjectInfected Antiretroviral-Naïveen_US
dc.subjectARV-naïveen_US
dc.subjectHuman immunodeficiency virusen_US
dc.titleShort Communication HIV Type 1 Transmitted Drug Resistance and Evidence of Transmission Clusters among Recently Infected Antiretroviral-Naive Individuals from Ugandan Fishing Communities of Lake Victoriaen_US
dc.typeArticleen_US
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The final, definitive version of this paper has been published in Aids Research and Human Retroviruses. Vol. 29 No. 5 (2013). Published by Mary Ann Liebert, Inc. DOI: 10.1089/aid.2012.0123. All rights reserved.
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