Tuberculosis Case Finding in First-Degree Relative Contacts Not Living With Index Tuberculosis Cases in Kampala, Uganda

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dc.contributor.authorChheng, Phalkun
dc.contributor.authorNsereko, Mary
dc.contributor.authorMalone, L aShaunda L
dc.contributor.authorOkware, Brenda
dc.contributor.authorZalwango, S arah
dc.contributor.authorJoloba, Moses
dc.contributor.authorBoom, W Henry
dc.contributor.authorMupere, Ezekiel
dc.contributor.authorStein, Catherine M
dc.date.accessioned2018-12-18T07:09:17Z
dc.date.available2018-12-18T07:09:17Z
dc.date.issued2015-10
dc.descriptionTo assess the prevalence of pulmonary tuberculosis among first-degree relative (FDR) contacts not living with tuberculosis (TB) casesen_US
dc.description.abstractPurpose: To assess the prevalence of pulmonary tuberculosis among first-degree relative (FDR) contacts not living with tuberculosis (TB) cases. Methods: A cross-sectional analysis of household contacts living with an index TB case and FDR contacts living outside of households in Kampala, Uganda, is presented. Results: A total of 177 contacts (52 FDRs and 125 index household contacts) of 31 TB cases were examined. Compared with index household contacts, FDR contacts were older, more likely to be TB symptomatic (50% vs 33%), had a higher percentage of abnormal chest X-rays (19% vs 11%), sputum smear positive (15% vs 5%), and many similar epidemiologic risk factors, including HIV infection (13% vs 10%). Contact groups had similar pulmonary tuberculosis prevalence: 9.6% in FDR vs 10.4% in index household contacts and similar Mycobacterium tuberculosis infection: 62% in FDR vs 61% in index households. Conclusion: TB is common among FDR contacts. High TB prevalence justifies targeting FDRs during household contact investigations. Combining TB active-case finding among FDR contacts with household contact investigation in low-income setting is feasible. This should be part of national TB control program strategies for increasing TB case-detection rates and reducing community TB transmission and death.en_US
dc.identifier.citationChheng, Phalkun, Nsereko, Mary, Malone, L aShaunda L, Okware, Brenda, Zalwango, S arah, Joloba, Moses, Boom, W Henry, Mupere, Ezekiel, Stein, Catherine M, 2015. Tuberculosis case finding in first-degree relative contacts not living with index tuberculosis cases in Kampala, Uganda, Clinical Epidemiology, Volume 2015:7 Pages 411—419; DOI https://doi.org/10.2147/CLEP.S82389en_US
dc.identifier.urihttps://hdl.handle.net/20.500.11951/655
dc.language.isoenen_US
dc.publisherClinical Epidemiologyen_US
dc.subjectPrevalence of pulmonary tuberculosisen_US
dc.subjectLimited resource settingen_US
dc.subjectContact tracingen_US
dc.titleTuberculosis Case Finding in First-Degree Relative Contacts Not Living With Index Tuberculosis Cases in Kampala, Ugandaen_US
dc.typeArticleen_US
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