Impact of High Human Genetic Diversity in Africa on Immunogenicity and Efficacy of RTS, S/AS01 Vaccine

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dc.contributor.authorStephen Tukwasibwe
dc.contributor.authorIsaac Ssewanyana
dc.contributor.authorGerald Mboowa
dc.contributor.authorIvan Sserwadda
dc.contributor.authorJoaniter
dc.contributor.authorNankabirwa
dc.contributor.authorEmmanuel Arinaitwe
dc.contributor.authorIsaac Ssewanyana
dc.contributor.authorYoweri Taremwa
dc.contributor.authorGerald Tumusiime
dc.contributor.authorMoses R. Kamya
dc.contributor.authorPrasanna Jagannathan
dc.contributor.authorAnnettee Nakimuli
dc.date.accessioned2024-04-22T09:58:35Z
dc.date.available2024-04-22T09:58:35Z
dc.date.issued2023-04-21
dc.descriptionJournal Article
dc.description.abstractIn modern medicine, vaccination is one of the most effective public health strategies to prevent infectious diseases. Indisputably, vaccines have saved millions of lives by reducing the burden of many serious infections such as polio, tuberculosis, measles, pneumonia, and tetanus. Despite the recent recommendation by the World Health Organization (WHO) to roll out RTS,S/AS01, this malaria vaccine still faces major challenges of variability in its efficacy partly due to high genetic variation in humans and malaria parasites. Immune responses to malaria vary between individuals and populations. Human genetic variation in immune system genes is the probable cause for this heterogeneity. In this review, we will focus on human genetic factors that determine variable responses to vaccination and how variation in immune system genes affect the immunogenicity and efficacy of the RTS,S/AS01 vaccine.
dc.identifier.citationTukwasibwe, S., Mboowa, G., Sserwadda, I. et al. Impact of high human genetic diversity in Africa on immunogenicity and efficacy of RTS,S/AS01 vaccine. Immunogenetics 75, 207–214 (2023). https://doi.org/10.1007/s00251-023-01306-8
dc.identifier.issnhttps://doi.org/10.1007/s00251-023-01306-8
dc.identifier.urihttps://hdl.handle.net/20.500.11951/1218
dc.language.isoen
dc.publisherSpringer
dc.titleImpact of High Human Genetic Diversity in Africa on Immunogenicity and Efficacy of RTS, S/AS01 Vaccine
dc.typeArticle
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