Prevalence and risk factors of latent Tuberculosis among adolescents in rural Eastern Uganda

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dc.contributor.authorMumpe-Mwanja, Daniel
dc.contributor.authorVerver, Suzanne
dc.contributor.authorYeka, Adoke
dc.contributor.authorEtwom, Alfred
dc.contributor.authorWaako, James
dc.contributor.authorSsengooba, Willy
dc.contributor.authorMatovu, Joseph K. B.
dc.contributor.authorWanyenze, Rhoda K.
dc.contributor.authorMusoke, Phillipa
dc.contributor.authorMayanja-Kizza, Harriet
dc.date.accessioned2018-07-26T10:30:58Z
dc.date.available2018-07-26T10:30:58Z
dc.date.issued2015-09
dc.description.abstractBackground: Latent Tuberculosis treatment is a key tuberculosis control intervention. Adolescents are a high risk group that is not routinely treated in low income countries. Knowledge of latent Tuberculosis (TB) burden among adolescents may influence policy. Objectives: We determined the prevalence and risk factors of latent TB infection among adolescents in rural Uganda. Methods: We analyzed baseline data from a study that assessed the prevalence and incidence of Tuberculosis disease among adolescents. We extracted socio-demographics, medical assessment information, and tuberculin skin test results and estimated prevalence ratios (PR) of latent TB infection risk factors by binomial regression. Results: The prevalence of latent TB was 16.1%, 95% CI (15.1 – 17.2). Significant risk factors were: a BCG scar, APR 1.29 (95% CI 1.12 – 1.48); male gender, APR 1.37 (95% CI 1.21 – 1.56); age 17 -18 years, APR 1.46 (95% CI 1.24 – 1.71) and 15-16 years, APR 1.25 (95% CI 1.07 – 1.46) compared to 12-14 years; being out of school, APR 1.31 (95% CI 1.05 – 1.62); and a known history of household TB contact in last 2 years, APR 1.91 (95% CI 1.55 – 2.35). Conclusion: Targeted routine latent TB treatment among adolescents out of school may be crucial for TB disease control in low income countries.en_US
dc.identifier.citationMumpe-Mwanja D, Verver S, Yeka A, Etwom A, Waako J, Ssengooba W, Matovu JKB, Wanyenze RK, Musoke P, Mayanja-Kizza H. Prevalence and predictors of latent Tuberculosis among adolescents in rural Eastern Uganda. Afri Health Sci. 2015;15(3):851-60. doi: http://dx.doi.org/10.4314/ahs.v15i3.20en_US
dc.identifier.issn1680-6905
dc.identifier.urihttps://hdl.handle.net/20.500.11951/313
dc.language.isoenen_US
dc.publisherPubMed Centralen_US
dc.subjectLatent tuberculosis infectionen_US
dc.subjectTuberculin skin testingen_US
dc.subjectTuberculosis infection in Adolescents - Ugandaen_US
dc.subjectTuberculosis - Risk factors - Uganda
dc.titlePrevalence and risk factors of latent Tuberculosis among adolescents in rural Eastern Ugandaen_US
dc.typeArticleen_US
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