Impact of Geographic Distance on Appraisal Delay for Active TB Treatment Seeking in Uganda: A Network Analysis of the Kawempe Community Health Cohort Study

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dc.contributor.authorFluegge, Kyle
dc.contributor.authorMalone, LaShaunda L.
dc.contributor.authorNsereko, Mary
dc.contributor.authorOkware, Brenda
dc.contributor.authorWejse, Christian
dc.contributor.authorKisingo, Hussein
dc.contributor.authorMupere, Ezekiel
dc.contributor.authorBoom, W. Henry
dc.contributor.authorStein, Catherine M.
dc.date.accessioned2018-12-17T14:22:43Z
dc.date.available2018-12-17T14:22:43Z
dc.date.issued2018-05
dc.descriptionThe study’s objective was to determine the association between appraisal delay in seeking tuberculosis (TB) treatment and geographic distance measured by network travel (driving and pedestrian) time (in minutes) and distance (Euclidean and self-reported) (in kilometers) and to identify other risk factors from selected covariates and how they modify the core association between delay and distance.en_US
dc.description.abstractBackground: Appraisal delay is the time a patient takes to consider a symptom as not only noticeable, but a sign of illness. The study’s objective was to determine the association between appraisal delay in seeking tuberculosis (TB) treatment and geographic distance measured by network travel (driving and pedestrian) time (in minutes) and distance (Euclidean and self-reported) (in kilometers) and to identify other risk factors from selected covariates and how they modify the core association between delay and distance. Methods: This was part of a longitudinal cohort study known as the Kawempe Community Health Study based in Kampala, Uganda. The study enrolled households from April 2002 to July 2012. Multivariable interval regression with multiplicative heteroscedasticity was used to assess the impact of time and distance on delay. The delay interval outcome was defined using a comprehensive set of 28 possible self-reported symptoms. The main independent variables were network travel time (in minutes) and Euclidean distance (in kilometers). Other covariates were organized according to the Andersen utilization conceptual framework. Results: A total of 838 patients with both distance and delay data were included in the network analysis. Bivariate analyses did not reveal a significant association of any distance metric with the delay outcome. However, adjusting for patient characteristics and cavitary disease status, the multivariable model indicated that each minute of driving time to the clinic significantly (p = 0.02) and positively predicted 0.25 days’ delay. At the median distance value of 47 min, this represented an additional delay of about 12 (95% CI: [3, 21]) days to the mean of 40 days (95% CI: [25, 56]). Increasing Euclidean distance significantly predicted (p = 0.02) reduced variance in the delay outcome, thereby increasing precision of the mean delay estimate. At the median Euclidean distance of 2.8 km, the variance in the delay was reduced by more than 25%. Conclusion: Of the four geographic distance measures, network travel driving time was a better and more robust predictor of mean delay in this setting. Including network travel driving time with other risk factors may be important in identifying populations especially vulnerable to delay.en_US
dc.identifier.citationFluegge, Kyle, Malone, LaShaunda L., Nsereko, Mary, Okware, Brenda, Wejse, Christian, Kisingo, Hussein, Mupere, Ezekiel, Boom, W. Henry, Stein, Catherine M., 2018. Impact of geographic distance on appraisal delay for active TB treatment seeking in Uganda: a network analysis of the Kawempe Community Health Cohort Study, BMC Public Health, 18:798; https://doi.org/10.1186/s12889-018-5648-6.en_US
dc.identifier.issn1471-2458
dc.identifier.urihttps://hdl.handle.net/20.500.11951/639
dc.language.isoenen_US
dc.publisherBMC Public Healthen_US
dc.subjectHealthcare accessen_US
dc.subjectMycobacterium tuberculosisen_US
dc.subjectTreatment delayen_US
dc.subjectHealth services researchen_US
dc.titleImpact of Geographic Distance on Appraisal Delay for Active TB Treatment Seeking in Uganda: A Network Analysis of the Kawempe Community Health Cohort Studyen_US
dc.typeArticleen_US
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