Pertussis Prevalence and Its Determinants Among Children With Persistent Cough in Urban Uganda

Simple item page
dc.contributor.authorKayina, Vincent
dc.contributor.authorKyobe, Samuel
dc.contributor.authorKatabazi, Fred A.
dc.contributor.authorKigozi, Edgar
dc.contributor.authorOkee, Moses
dc.contributor.authorOdongkara, Beatrice
dc.contributor.authorBabikako, Harriet M.
dc.contributor.authorWhalen, Christopher C.
dc.contributor.authorJoloba, Moses L.
dc.contributor.authorMusoke, Philippa M.
dc.contributor.authorMupere, Ezekiel
dc.date.accessioned2018-12-18T09:24:54Z
dc.date.available2018-12-18T09:24:54Z
dc.date.issued2015-04
dc.descriptionThe study determined prevalence of pertussis infection and its associated host and environmental factors to generate information that would guide strategies for disease control.en_US
dc.description.abstractBackground We determined prevalence of pertussis infection and its associated host and environmental factors to generate information that would guide strategies for disease control. Methods In a cross-sectional study, 449 children aged 3 months to 12 years with persistent cough lasting 14 days were enrolled and evaluated for pertussis using DNA polymerase chain reaction (PCR) and ELISA serology tests. Results Pertussis prevalence was 67 (15% (95% Confidence Interval (CI): 12–18)) and 81 (20% (95% CI:16–24)) by PCR and ELISA, respectively among 449 participating children. The prevalence was highest in children with >59 months of age despite high vaccination coverage of 94% in this age group. Study demographic and clinical characteristics were similar between pertussis and non-pertussis cases. Of the 449 children, 133 (30%) had a coughing household member and 316 (70%) did not. Among 133 children that had a coughing household member, sex of child, sharing bed with a coughing household member and having a coughing individual in the neighborhood were factors associated with pertussis. Children that had shared a bed with a coughing household individual had seven-fold likelihood of having pertussis compared to children that did not (odds ratio (OR) 7.16 (95% CI: 1.24–41.44)). Among the 316 children that did not have a coughing household member, age <23 months, having or contact with a coughing individual in neighborhood, a residence with one room, and having a caretaker with >40 years of age were the factors associated with pertussis. Age <23months was three times more likely to be associated with pertussis compared to age 24–59 months (OR 2.97 (95% CI: 1.07–8.28)). Conclusion Findings suggest high prevalence of pertussis among children with persistent cough at a health facility and it was marked in children >59 months of age, suggesting the possibility of waning immunity. The factors associated with pertussis varied by presence or absence of a coughing household member.en_US
dc.identifier.citationKayina V, Kyobe S, Katabazi FA, Kigozi E, Okee M, Odongkara B, et al. (2015) Pertussis Prevalence and Its Determinants among Children with Persistent Cough in Urban Uganda. PLoS ONE 10(4): e0123240. doi:10.1371/journal.pone.0123240en_US
dc.identifier.urihttps://hdl.handle.net/20.500.11951/667
dc.language.isoenen_US
dc.publisherPLoS ONEen_US
dc.subjectPertussisen_US
dc.subjectChildrenen_US
dc.subjectPersistent Coughen_US
dc.subjectUgandaen_US
dc.titlePertussis Prevalence and Its Determinants Among Children With Persistent Cough in Urban Ugandaen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Kayina_et al._Pertussis Prevalence and Its Determinants among Children with Persistent Cough in Urban Uganda_2015.PDF
Size:
232.1 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
UCU School of Medicine