Transition From F-75 to Ready-to-Use Therapeutic Food in Children With Severe Acute Malnutrition, an Observational Study in Uganda

Simple item page
dc.contributor.authorLanyero, Betty
dc.contributor.authorNamusoke, Hanifa
dc.contributor.authorNabukeera-Barungi, Nicolette
dc.contributor.authorGrenov, Benedikte
dc.contributor.authorMupere, Ezekiel
dc.contributor.authorMichaelsen, Kim Fleischer
dc.contributor.authorMølgaard, Christian
dc.contributor.authorChristensen, Vibeke Brix
dc.contributor.authorFriis, Henrik
dc.contributor.authorBriend, André
dc.date.accessioned2018-12-18T06:21:32Z
dc.date.available2018-12-18T06:21:32Z
dc.date.issued2017-08
dc.descriptionAn observational study was conducted among children aged 6–59 months treated for SAM at Mulago hospital, Kampala, Uganda.en_US
dc.description.abstractBackground World Health Organization now recommends the transition from F-75 to ready-to-use therapeutic foods (RUTF) in the management of severe acute malnutrition (SAM). We described the transition from F-75 to RUTF and identified correlates of failed transition. Methods We conducted an observational study among children aged 6–59 months treated for SAM at Mulago hospital, Kampala, Uganda. Therapeutic feeding during transition phase was provided by first offering half of the energy requirements from RUTF and the other half from F-75 and then increasing gradually to RUTF as only energy source. The child was considered to have successfully transitioned to RUTF if child was able to gradually consume up to 135 kcal/kg/day of RUTF in the transition phase on first attempt. Failed transition to RUTF included children who failed the acceptance test or those who had progressively reduced RUTF intake during the subsequent days. Failure also included those who developed profuse diarrhoea or vomiting when RUTF was ingested. Results Among 341 of 400 children that reached the transition period, 65% successfully transitioned from F-75 to RUTF on first attempt while 35% failed. The median (IQR) duration of the transition period was 4 (3–8) days. The age of the child, mid-upper arm circumference, weight-for-height z-score and weight at transition negatively predicted failure. Each month increase in age reflected a 4% lower likelihood of failure (OR 0.96 (95% CI 0.93; 0.99). Children with HIV (OR 2.73, 95% CI 1.27; 5.85) and those rated as severely ill by caregiver (OR 1.16, 95% CI: 1.02; 1.32) were more likely to fail. At the beginning of the rehabilitation phase, the majority (95%) of the children eventually accepted RUTF while only 5% completed rehabilitation in hospital on F-100. Conclusion Transition from F-75 to RUTF for hospitalized children with SAM by gradual increase of RUTF was possible on first attempt in 65% of cases. Younger children, severely wasted, HIV infected and those with severe illness as rated by the caregiver were more likely to fail to transit from F-75 to RUTF on first attempt.en_US
dc.identifier.citationLanyero, Betty, Namusoke, Hanifa, Nabukeera-Barungi, Nicolette, Grenov, Benedikte, Mupere, Ezekiel, Michaelsen, Kim Fleischer, Mølgaard, Christian, Christensen, Vibeke Brix, Friis, Henrik, Briend, André, 2017. Transition from F-75 to ready-to-use therapeutic food in children with severe acute malnutrition, an observational study in Uganda, Nutrition Journal, 16:52; https://doi.org/10.1186/s12937-017-0276-zen_US
dc.identifier.issn1475-2891
dc.identifier.urihttps://hdl.handle.net/20.500.11951/648
dc.language.isoenen_US
dc.publisherNutrition Journalen_US
dc.subjectSevere acute malnutritionen_US
dc.subjectTransitionen_US
dc.subjectRUTFen_US
dc.subjectChildrenen_US
dc.subjectUgandaen_US
dc.titleTransition From F-75 to Ready-to-Use Therapeutic Food in Children With Severe Acute Malnutrition, an Observational Study in Ugandaen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Lanyero_et al._Transition from F-75 to ready-to-use therapeutic_2017.pdf
Size:
462.18 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
UCU School of Medicine