Browsing by Author "Yahaya, James Joseph"

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BRCA1 Protein Expression in Epithelial Ovarian Cancer and Associated Clinicopathological Factors in Uganda
(Wiley, 2024-10-21) Okecha, Tonny; Abila, Derrick B.; Nabbale, Dorothy L.; Katongole, Fauz; Yahaya, James Joseph; Lukande Robert; Kalungi, Sam; Nalwoga, Hawa
BRCA1 gene dysfunction seen in epithelial ovarian carcinomas often results from germline mutations, somatic mutations, and promoter methylation. Identi0cation of tumors with loss of BRCA1 protein expression has shown to have therapeutic and prognostic implications. *e aim of this study was to determine the expression of BRCA1 protein in epithelial ovarian cancer (EOC) and the associated clinicopathological characteristics. This was a cross-sectional laboratory-based study that used para5n-embedded tissue blocks of patients histologically diagnosed with EOC from January 2010 to August 2018. Tissue sections were stained with hematoxylin and eosin (H&E) for histological con0rmation and with immunohistochemistry (IHC) using a mouse-derived monoclonal antibody MS110 for BRCA1 protein expression. *e association between BRCA1 protein expression and independent variables was determined using Pearson’s Chi-square test. A total of 104 tissue blocks from patients with EOC were included in the study with a mean age of 48.7 ± 12.8 years. Serous tumors were the most common which comprised 74.0% (77/104) of all the tumors and majority of them 75.3% (58/77) were high grade. Loss of expression of BRCA1 protein expression was found in 33.7% (33/98) of all the cases. *ere was no statistically signi0cant association between BRCA1 expression and age of patients, tumor grade, and histological subtype. There is a high expression of altered BRCA1 expression in tissues of EOC. Although it has not shown association with age of patients, histology types, and tumor grade, further studies need to assess its inCuence of the survival of cancer patients with EOC.
Prevalence and risk factors associated with hypopharyngo-esophageal foreign bodies impaction: a cross-sectional study
(Wiley, 2025-03-18) Kabazzi, Edrisa; Namwagala, Justine; Alunga, John R .; Byaruhanga, Richard; Okecha, Tonny; Yahaya, James Joseph
Ingestion of foreign bodies (FBs) is an emergency condition which may be associated with challenges for their removal. We aimed to assess the prevalence and factors associated with hypopharyngo-esophageal foreign bodies (HP-EFBs) impaction. A cross-sectional study was conducted at Mulago national referral hospital in Uganda from August 2018 to May 2019. The study consisted of 150 patients aged 6 months to 49 years with suspicion of HP-EFBs impaction. Binary logistic regression analysis was applied to determine factors associated with HP-EFBs. Statistical significance was set at P < 0.05. The median age of the patients was 7.1 (4.3–16.4) years, and males accounted for the majority (64%, n = 96) of the patients. Clinically, majority (62.0%, n = 93) of the patients had dysphagia. The prevalence of HP-EFBs was (33.3%, n = 50). Majority (76.0%, n = 38) of the FBs were coins. Being aged ≤5 years (aOR = 1.47, 95% CI = 2.18–3.39, P = 0.043), being a child attending school (aOR = 2.03, 95% CI = 1.56–4.92, P = 0.037), and being under caretakers aged ≤25 years (aOR = 6.83, 95% CI = 1.88–24.79), P = 0.003) were associated with increased risk of HP-EFBs impaction. This study has shown increased risk of HP-EFBs impaction particularly in male children and those attending school. Also, patients who were under younger caretakers had increased odds of HP-EFBs impaction. There is a need for caretakers and teachers at school to provide emphasis for children to always have precaution to avoid impaction of FBs.
Prognostic Factors for Overall Survival of Patients with Prostate Cancer in Kyadondo County, Uganda
(Hindawi, 2020-01-27) Yahaya, James Joseph; Okecha, Tonny; Odida, Michael; Wabinga, Henry
Prostate cancer is the second most common cancer among men globally. A few studies that have been done in Uganda on survival of patients with prostate cancer indicate that, the overall survival of patients with prostate cancer in Uganda is poor. The aim of this study was to determine the 3-year overall survival rate of a cohort of patients with prostate cancer residing in Kyadondo County who were diagnosed from 2012 to 2014. The secondary objective was to correlate the overall survival with the clinicopathological prognostic factors. Materials and Methods. This was a retrospective cohort study which involved 136 patients who were diagnosed histologically with prostate cancer at the department of pathology between 2012 and 2014. The cases were registered at the Kampala cancer registry and followed up to 31st December 2017. Data analysis was done using STATA version 12.0. The Kaplan-Meir curves were used for analysis of the 3-year overall survival rate. Hazard ratio (HR) and Log-rank test at 95% confidence interval under Cox-regression model were used to evaluate the effect of the covariates on the 3-year overall survival rate. < 0.05 was considered statistically significant. Results. More than half of the cases, 55.9% ( = 76) had Gleason score >8. Most of the patients, 67.7% ( = 92) had advanced disease at diagnosis. The 3-year overall survival rate was 67.6% with median survival of 36.5 months and range of 0–65 months. Clinical stage of the patients (HR = 1.65, = 0.039), Gleason score (HR = 1.88, = 0.008 ), and lymphovascular invasion (HR = 0.37, = 0.002) were the independent predictors of the 3-year overall survival rate in this study. Conclusion. The 3-year overall survival of prostate cancer patients in Uganda is poor. Most of the patients with are diagnosed with advanced clinical stages (stage III and IV). The Gleason score, clinical stage and lymphovascular invasion can powerfully predict independently the overall survival of patients with prostate cancer. This implies that the Gleason score, clinical stage and lymphovascular invasion may be used to predict the overall survival of patients with prostate cancer even prior prostatectomy.