Browsing by Author "Tonny Okecha"

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    ALK-1 positive anaplastic large cell lymphoma in sickle cell trait: a case report and review of literature
    (Journal of Case Reports and Scientific Images, 2024-01-13) Omega Phillip; Gimono Martha; Peter Wasswa; Musoke Sharrif; Tonny Okecha; Mawanda Anatoli; Asiimwe Ivan; Okello Malcom Mark; Oballim John Kennedy; Ojok Peter Boii; Wanyenze Esther; Byebei Eunice; Masumba John Dalton; Nakayemba Jolive; Kyakoonye Moses; Atuhura Ronald; Nsobya George; Boaz Mwesigwa; Lukande Robert; Bukirwa Phiona; Yekosani Mitala; Gladys Adokorach; Achola Caroline; Wabinga Henry; dida Micheal; Kalungi Sam
    Anaplastic large cell lymphoma (ALCL) is a rare subtype of non-Hodgkin lymphoma, with ALK-1 positive ALCL exhibiting an aggressive clinical course. However, it remains potentially curable if diagnosed in a timely manner. We present the case of a 13-year-old boy with coexisting sickle cell trait and ALK-1 positive ALCL, who presented with recurrent fever, progressive weight loss, generalized lymphadenopathy, and severe anemia. Despite aggressive supportive therapy, he succumbed within 32 hours of admission. Postmortem examination revealed extensive lymph node infiltration by tumor cells and widespread multi-organ involvement. This case underscores the diagnostic challenges associated with ALK-1 positive ALCL, particularly in pediatric patients with underlying hematologic conditions, and raises the possibility of a potential association between ALK-1 positive ALCL and sickle cell trait.
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    An unusual case of mesenteric schistosomiasis presenting as bowel obstruction in a child
    (ARC Journals, 2025-04-07) Omega Phillip; Musoke Sharrif; Tonny Okecha; Mawanda Anatoli; Boaz Mwesigwa; Asiimwe Ivan; Okello Malcom Mark; Gladys Adokorach; Oballim John Kennedy; Ojok Peter Boii; Wanyenze Esther; Byebei Eunice; Masumba John Dalton; Nakayemba Jolive; Kyakoonye Moses; Atuhura Ronald; Nsobya George; Lukande Robert; Bukirwa Phiona; Tumukunde Allan; Yekosani Mitala; Nabukalu Sandra; aratwebirwe Oseber; Odida Micheal; Kalungi Sam
    Mesenteric schistosomiasis is a rare but significant cause of intestinal obstruction, particularly in endemic regions. We report a case of a 12-year-old boy from Masese Landing Site, Uganda, who presented with progressive abdominal distension, vomiting, and constipation—symptoms indicative of bowel obstruction. Surgical exploration revealed extensive adhesions and nodular lesions, necessitating biopsies. Histopathological examination confirmed intestinal schistosomiasis caused by Schistosoma mansoni. This case highlights the need for heightened clinical awareness, early diagnosis, and prompt intervention in endemic areas to prevent complications of chronic schistosomiasis
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    Malignant mixed mullerian tumor: a case report about a uterine tumor’s case
    (Wolters Kluwer, 2022-05-20) Emmanuel D. Morgan; Tonny Okecha; James J. Yahaya; Emmanuel Othieno
    Introduction: Malignant mixed Mullerian tumor (MMMT) is an exceedingly rare and aggressive tumor whichoccurs predominantly in postmenopausal women though it has been reported rarely in premenopausal women.Case presentation: A 54-year old nulliparous postmenopausal female presented with a 3-month history of vaginalbleeding, mild lower abdominal pain and weight loss. Ultrasound revealed markedly enlarged uterus with ahyper-echoic solid and cystic mass and a right adnexal complex mass. Total abdominal hysterectomy andbilateral salpingioopherectomy were done. Histopathological features were consistent with MMMT. The patientis currently stable after 6 cycles of adjuvant chemotherapy which consisted of paclitaxel and carboplatin.Clinical discussion: MMMT of the uterus is rare, high-grade neoplasms comprising only 1–2% of uterine cancersand 3–5% of all uterine malignancies. This tumor may arise in the ovaries, fallopian tubes and vagina. Histologically, MMMT is a biphasic tumor composed of both epithelial (carcinoma) elements and mesenchymal(sarcoma) elements; though, which component is responsible for the tumor’s aggressive biological behavior remains undetermined.Conclusion: MMMT is a rare and aggressive tumor which is commonly seen in postmenopausal women with highrate of recurrence therefore, Radical surgery and close follow-up is mandatory since the role of chemoradiotherapy remains unclear in the management of patients with this tumor. Both stage of the tumor andmyometrial invasion are considered as potential prognostic factors.