Browsing by Author "Kalungi Sam"

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    Aids-Related Disseminated Kaposi Sarcoma with Renal Involvement: A Rare Non-Transplant Case Report
    (2025-04-01) Omega, Phillip; Musoke Sharrif; Alele David; Okecha, Tonny; Mawanda Anatoli; Mwesigwa, Boaz; Adokorach, Gladys; Lukande Robert; Kalungi Sam
    Kaposi’s sarcoma (KS) is a vascular malignancy associated with human herpesvirus 8 (HHV-8). In Africa, the commonest type is the AIDS-associated KS seen in immunocompromised individuals, infected with HIV. Although KS primarily affects the skin and mucosal surfaces, visceral involvement is also well-documented, with the lungs and gastrointestinal tract being the most frequently affected sites. Renal involvement in non-transplant patients remains exceptionally rare. We present a case of a 33-year-old HIV-positive woman with a history of non-adherence to highly active antiretroviral therapy (HAART), who developed disseminated KS involving the oral mucosa, lungs, gastrointestinal tract, liver, and the right kidney. She presented with respiratory distress, generalized lymphadenopathy, and a hyperpigmented sublingual mass. Histopathological examination of the oral lesion confirmed KS, and post-mortem findings revealed extensive tumor infiltration of multiple organs, including the right kidney. This case highlights the aggressive nature of disseminated KS in severely immunocompromised patients and underscores the critical importance of HAART adherence in preventing disease progression. Given the exceptional rarity of non-allograft renal KS, this report adds to the limited literature on its occurrence and emphasizes the need for heightened clinical awareness when evaluating advanced KS cases.
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    ALK-1 positive anaplastic large cell lymphoma in sickle cell trait: a case report and review of literature
    (Journal of Case Reports and Scientific Images, 2024-01-13) Omega Phillip; Gimono Martha; Peter Wasswa; Musoke Sharrif; Tonny Okecha; Mawanda Anatoli; Asiimwe Ivan; Okello Malcom Mark; Oballim John Kennedy; Ojok Peter Boii; Wanyenze Esther; Byebei Eunice; Masumba John Dalton; Nakayemba Jolive; Kyakoonye Moses; Atuhura Ronald; Nsobya George; Boaz Mwesigwa; Lukande Robert; Bukirwa Phiona; Yekosani Mitala; Gladys Adokorach; Achola Caroline; Wabinga Henry; dida Micheal; Kalungi Sam
    Anaplastic large cell lymphoma (ALCL) is a rare subtype of non-Hodgkin lymphoma, with ALK-1 positive ALCL exhibiting an aggressive clinical course. However, it remains potentially curable if diagnosed in a timely manner. We present the case of a 13-year-old boy with coexisting sickle cell trait and ALK-1 positive ALCL, who presented with recurrent fever, progressive weight loss, generalized lymphadenopathy, and severe anemia. Despite aggressive supportive therapy, he succumbed within 32 hours of admission. Postmortem examination revealed extensive lymph node infiltration by tumor cells and widespread multi-organ involvement. This case underscores the diagnostic challenges associated with ALK-1 positive ALCL, particularly in pediatric patients with underlying hematologic conditions, and raises the possibility of a potential association between ALK-1 positive ALCL and sickle cell trait.
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    An unusual case of mesenteric schistosomiasis presenting as bowel obstruction in a child
    (ARC Journals, 2025-04-07) Omega Phillip; Musoke Sharrif; Tonny Okecha; Mawanda Anatoli; Boaz Mwesigwa; Asiimwe Ivan; Okello Malcom Mark; Gladys Adokorach; Oballim John Kennedy; Ojok Peter Boii; Wanyenze Esther; Byebei Eunice; Masumba John Dalton; Nakayemba Jolive; Kyakoonye Moses; Atuhura Ronald; Nsobya George; Lukande Robert; Bukirwa Phiona; Tumukunde Allan; Yekosani Mitala; Nabukalu Sandra; aratwebirwe Oseber; Odida Micheal; Kalungi Sam
    Mesenteric schistosomiasis is a rare but significant cause of intestinal obstruction, particularly in endemic regions. We report a case of a 12-year-old boy from Masese Landing Site, Uganda, who presented with progressive abdominal distension, vomiting, and constipation—symptoms indicative of bowel obstruction. Surgical exploration revealed extensive adhesions and nodular lesions, necessitating biopsies. Histopathological examination confirmed intestinal schistosomiasis caused by Schistosoma mansoni. This case highlights the need for heightened clinical awareness, early diagnosis, and prompt intervention in endemic areas to prevent complications of chronic schistosomiasis