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    Real-Time Molecular Monitoring of Chemical Environment in Obligate Anaerobes during Oxygen Adaptive Response

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    The final, definitive version of this paper has been published in Lawrence Berkeley National Laboratory. California Digital Library, University of California. (26/08/ 2009). All rights reserved. (478.7Kb)
    Date
    2009-08-26
    Author
    Holman, Hoi-Ying N.
    Wozei, Eleanor
    Lin, Zhang
    Comolli, Luis R.
    Ball, David. A.
    Borglin, Sharon
    Fields, Matthew W.
    Hazen, Terry C.
    Downing, Kenneth H.
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    Abstract
    Determining the transient chemical properties of the intracellular environment can elucidate the paths through which a biological system adapts to changes in its environment, for example, the mechanisms which enable some obligate anaerobic bacteria to survive a sudden exposure to oxygen. Here we used high-resolution Fourier Transform Infrared (FTIR) spectromicroscopy to continuously follow cellular chemistry within living obligate anaerobes by monitoring hydrogen bonding in their cellular water. We observed a sequence of well-orchestrated molecular events that correspond to changes in cellular processes in those cells that survive, but only accumulation of radicals in those that do not. We thereby can interpret the adaptive response in terms of transient intracellular chemistry and link it to oxygen stress and survival. This ability to monitor chemical changes at the molecular level can yield important insights into a wide range of adaptive responses.
    Use this URI to cite this item:
    https://hdl.handle.net/20.500.11951/359
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