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    Prevalence and risk factors of latent Tuberculosis among adolescents in rural Eastern Uganda

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    Research article (438.3Kb)
    Date
    2015-09
    Author
    Mumpe-Mwanja, Daniel
    Verver, Suzanne
    Yeka, Adoke
    Etwom, Alfred
    Waako, James
    Ssengooba, Willy
    Matovu, Joseph K. B.
    Wanyenze, Rhoda K.
    Musoke, Phillipa
    Mayanja-Kizza, Harriet
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    Abstract
    Background: Latent Tuberculosis treatment is a key tuberculosis control intervention. Adolescents are a high risk group that is not routinely treated in low income countries. Knowledge of latent Tuberculosis (TB) burden among adolescents may influence policy. Objectives: We determined the prevalence and risk factors of latent TB infection among adolescents in rural Uganda. Methods: We analyzed baseline data from a study that assessed the prevalence and incidence of Tuberculosis disease among adolescents. We extracted socio-demographics, medical assessment information, and tuberculin skin test results and estimated prevalence ratios (PR) of latent TB infection risk factors by binomial regression. Results: The prevalence of latent TB was 16.1%, 95% CI (15.1 – 17.2). Significant risk factors were: a BCG scar, APR 1.29 (95% CI 1.12 – 1.48); male gender, APR 1.37 (95% CI 1.21 – 1.56); age 17 -18 years, APR 1.46 (95% CI 1.24 – 1.71) and 15-16 years, APR 1.25 (95% CI 1.07 – 1.46) compared to 12-14 years; being out of school, APR 1.31 (95% CI 1.05 – 1.62); and a known history of household TB contact in last 2 years, APR 1.91 (95% CI 1.55 – 2.35). Conclusion: Targeted routine latent TB treatment among adolescents out of school may be crucial for TB disease control in low income countries.
    Use this URI to cite this item:
    https://hdl.handle.net/20.500.11951/313
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