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Widespread Pyrethroid and DDT Resistance in the Major Malaria Vector Anopheles funestus in East Africa Is Driven by Metabolic Resistance Mechanisms

Mulamba, Charles; Riveron, Jacob M.; Ibrahim, Sulaiman S.; Irving, Helen; Barnes, Kayla G.; Mukwaya, Louis G.; Birungi, Josephine; Wondji, Charles S. (2014-10-15)

Background Establishing the extent, geographical distribution and mechanisms of insecticide resistance in malaria vectors is a prerequisite for resistance management. Here, we report a widespread distribution of insecticide ...

Immune activation alters cellular and humoral responses to yellow fever 17D vaccine

Muyanja, Enoch; Ssemaganda, Aloysius; Ngauv, Pearline; Cubas, Rafael; Perrin, Helene; Srinivasan, Divya; Canderan, Glenda; Lawson, Benton; Kopycinski, Jakub; Graham, Amanda S.; Rowe, Dawne K.; Smith, Michaela J.; Isern, Sharon; Michael, Scott; Silvestri, Guido; Vanderford, Thomas H.; Castro, Erika; Pantaleo, Giuseppe; Singer, Joel; Gillmour, Jill; Kiwanuka, Noah; Nanvubya, Annet; Schmidt, Claudia; Birungi, Josephine; Cox, Josephine; Haddad, Elias K.; Kaleebu, Pontiano; Fast, Patricia; Sekaly, Rafick-Pierre; Trautmann, Lydie (The Journal of Clinical Investigation, 2014-07)

Background. Defining the parameters that modulate vaccine responses in African populations will be imperative to design effective vaccines for protection against HIV, malaria, tuberculosis, and dengue virus infections. This ...

A lab-on-chip for malaria diagnosis and surveillance

Taylor, Brian J.; Howell, Anita; Martin, Kimberly A.; Manage, Dammika P.; Gordy, Walter; Campbell, Stephanie D.; Lam, Samantha; Jin, Albert; Polley, Spncer D.; Samuel, Roshini A.; Atrazhev, Alexey; Stickel, Alex J.; Birungi, Josephine; Mbonye, Anthony K.; Pilarski, Linda M.; Acker, Jason P.; Yanow, Stephanie K. (BioMed Central Ltd., 2014-05-09)

Background: Access to timely and accurate diagnostic tests has a significant impact in the management of diseases of global concern such as malaria. While molecular diagnostics satisfy this need effectively in developed ...

Prescription patterns and drug use among pregnant women with febrile Illnesses in Uganda: a survey in out-patient clinics.

Mbonye, Anthony K.; Birungi, Josephine; Yanow, Stephanie; Magnussen, Pascal (2013)

Background: Malaria is a public health problem in Uganda; affecting mainly women and children. Effective treatment has been hampered by over-diagnosis and over-treatment with anti-malarial drugs among patients presenting ...