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A single-nucleotide-polymorphism real-time PCR assay for genotyping of Mycobacterium tuberculosis complex in peri-urban Kampala

Wampande, Eddie M.; Hatzios, Stavroula K.; Achan, Beatrice; Mupere, Ezekiel; Nsereko, Mary; Mayanja, Harriet K.; Eisenach, Kathleen; Boom, W Henry; Gagneux, Sebastien; Joloba, Moses L. (BMC Infectious Diseases, 2015-09)

Background: Accurate and high-throughput genotyping of Mycobacterium tuberculosis complex (MTBC) may be important for understanding the epidemiology and pathogenesis of tuberculosis (TB). In this study, we report the ...

Changes in whole-blood PUFA and their predictors during recovery from severe acute malnutrition

Babirekere-Iriso, Esther; Mortensen, Charlotte G.; Mupere, Ezekiel; Rytter, Maren J. H.; Namusoke, Hanifa; Michaelsen, Kim F.; Briend, André; Stark, Ken D.; Friis, Henrik; Lauritzen, Lotte (British Journal of Nutrition, 2016-05)

Children with severe acute malnutrition (SAM) with complications require in-patient management including therapeutic feeding. Little attention has been given to the effects of these feeds on the essential fatty acid status ...

Impact of geographic distance on appraisal delay for active TB treatment seeking in Uganda: a network analysis of the Kawempe Community Health Cohort Study

Fluegge, Kyle; Malone, LaShaunda L.; Nsereko, Mary; Okware, Brenda; Wejse, Christian; Kisingo, Hussein; Mupere, Ezekiel; Boom, W. Henry; Stein, Catherine M. (BMC Public Health, 2018-05)

Background: Appraisal delay is the time a patient takes to consider a symptom as not only noticeable, but a sign of illness. The study’s objective was to determine the association between appraisal delay in seeking ...

Feasibility, reliability and validity of health-related quality of life questionnaire among adult pulmonary tuberculosis patients in urban Uganda: cross-sectional study

Babikako, Harriet M; Neuhauser, Duncan; Katamba, Achilles; Mupere, Ezekiel (Health and Quality of Life Outcomes, 2010-09)

Background Despite the availability of standard instruments for evaluating health-related quality life (HRQoL), the feasibility, reliability, and validity of such instruments among tuberculosis (TB) patients in different ...

High incidence of pulmonary tuberculosis in children admitted with severe pneumonia in Uganda

Nantongo, Josephine M; Wobudeya, Eric; Mupere, Ezekiel; Joloba, Moses; Ssengooba, Willy; Kisembo, Harriet N; Lubega, Irene R; Musoke, Philippa M (BMC Pediatrics, 2013-01)

Background A high prevalence of tuberculosis (TB) in children presenting with severe pneumonia has previously been reported in South Africa. However, little is known about TB among children with pneumonia in Uganda and ...

Long-term dominance of Mycobacterium tuberculosis Uganda family in peri-urban Kampala-Uganda is not associated with cavitary disease

Wampande, Eddie M; Mupere, Ezekiel; Debanne, SaraM; Asiimwe, Benon B; Nsereko, Mary; Mayanja, Harriet; Eisenach, Kathleen; Kaplan, Gilla; Boom, Henry W; Gagneux, Sebastien; Joloba, Moses L (BMC Infectious Diseases, 2013-10)

Background Previous studies have shown that Mycobacterium tuberculosis (MTB) Uganda family, a sub-lineage of the MTB Lineage 4, is the main cause of tuberculosis (TB) in Uganda. Using a well characterized patient population, ...

Pertussis Prevalence and Its Determinants among Children with Persistent Cough in Urban Uganda

Kayina, Vincent; Kyobe, Samuel; Katabazi, Fred A.; Kigozi, Edgar; Okee, Moses; Odongkara, Beatrice; Babikako, Harriet M.; Whalen, Christopher C.; Joloba, Moses L.; Musoke, Philippa M.; Mupere, Ezekiel (PLoS ONE, 2015-04)

Background We determined prevalence of pertussis infection and its associated host and environmental factors to generate information that would guide strategies for disease control. Methods In a cross-sectional study, ...

Male gender and duration of anti-tuberculosis treatment are associated with hypocholesterolemia in adult pulmonary tuberculosis patients in Kampala, Uganda

Mukisa, John; Kawooya, Ismael; Nangendo, Joan; Nalutaaya, Annet; Nyamwiza, Jean; Sam, Ali; Ssenyonga, Ronald; Worodria, William; Mupere, Ezekiel (African Health Sciences, 2018-09)

Background: Patients with Pulmonary tuberculosis (PTB) and hypocholesterolemia have an altered immune function, delayed sputum conversion at two months and increased mortality. However, the assessment for dyslipidemias is ...

Patient satisfaction, feasibility and reliability of satisfaction questionnaire among patients with pulmonary tuberculosis in urban Uganda: a cross-sectional study

Babikako, Harriet M; Neuhauser, Duncan; Katamba, Achilles; Mupere, Ezekiel (Health Research Policy and Systems, 2011-01)

Background A comprehensive understanding of the barriers to and facilitators of poor tuberculosis (TB) treatment outcome is still lacking; posing a major obstacle to finding effective solutions. Assessment of patient ...

Wasting among Uganda men with pulmonary tuberculosis is associated with linear regain in lean tissue mass during and after treatment in contrast to women with wasting who regain fat tissue mass: prospective cohort study

Mupere, Ezekiel; Malone, LaShaunda; Zalwango, Sarah; Okwera, Alphonse; Nsereko, Mary; Tisch, Daniel J; Parraga, Isabel M; Stein, Catherine M; Mugerwa, Roy; Boom, W Henry; Mayanja, Harriet K; Whalen, Christopher C (BMC Infectious Diseases, 2014-01)

Background: Nutritional changes during and after tuberculosis treatment have not been well described. We therefore determined the effect of wasting on rate of mean change in lean tissue and fat mass as measured by bioelectrical ...