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dc.contributor.authorMupere, Ezekiel
dc.contributor.authorMalone, LaShaunda
dc.contributor.authorZalwango, Sarah
dc.contributor.authorOkwera, Alphonse
dc.contributor.authorNsereko, Mary
dc.contributor.authorTisch, Daniel J
dc.contributor.authorParraga, Isabel M
dc.contributor.authorStein, Catherine M
dc.contributor.authorMugerwa, Roy
dc.contributor.authorBoom, W Henry
dc.contributor.authorMayanja, Harriet K
dc.contributor.authorWhalen, Christopher C
dc.date.accessioned2018-12-17T13:35:52Z
dc.date.available2018-12-17T13:35:52Z
dc.date.issued2014-01
dc.identifier.citationMupere, Ezekiel, Malone, LaShaunda, Zalwango, Sarah, Okwera, Alphonse, Nsereko, Mary, Tisch, Daniel J, Parraga, Isabel M, Stein, Catherine M, Mugerwa, Roy, Boom, W Henry, Mayanja,, Harriet K, Whalen, Christopher C, 2014. Wasting among Uganda men with pulmonary tuberculosis is associated with linear regain in lean tissue mass during and after treatment in contrast to women with wasting who regain fat tissue mass: prospective cohort study, 14:24; https://doi.org/10.1186/1471-2334-14-24en_US
dc.identifier.issn1471-2334
dc.identifier.urihttps://hdl.handle.net/20.500.11951/633
dc.descriptionNutritional changes during and after tuberculosis treatment have not been well described. We therefore determined the effect of wasting on rate of mean change in lean tissue and fat mass as measured by bioelectrical impedance analysis (BIA), and mean change in body mass index (BMI) during and after tuberculosis treatment.en_US
dc.description.abstractBackground: Nutritional changes during and after tuberculosis treatment have not been well described. We therefore determined the effect of wasting on rate of mean change in lean tissue and fat mass as measured by bioelectrical impedance analysis (BIA), and mean change in body mass index (BMI) during and after tuberculosis treatment. Methods: In a prospective cohort study of 717 adult patients, BMI and height-normalized indices of lean tissue (LMI) and fat mass (FMI) as measured by BIA were assessed at baseline, 3, 12, and 24 months. Results: Men with wasting at baseline regained LMI at a greater rate than FMI (4.55 kg/m2 (95% confidence interval (CI): 1.26, 7.83 versus 3.16 (95% CI: 0.80, 5.52)) per month, respectively during initial tuberculosis therapy. In contrast, women with wasting regained FMI at greater rate than LMI (3.55 kg/m2 (95% CI: 0.40, 6.70) versus 2.07 (95% CI: -0.74,4.88)), respectively. Men with wasting regained BMI at a rate of 6.45 kg/m2 (95% CI: 3.02, 9.87) in the first three months whereas women, had a rate of 3.30 kg/m2 (95% CI: -0.11, 6.72). There were minimal changes in body composition after month 3 and during months 12 to 24. Conclusion: Wasted tuberculosis patients regain weight with treatment but the type of gain differs by gender and patients may remain underweight after the initial phase of treatment.en_US
dc.language.isoenen_US
dc.publisherBMC Infectious Diseasesen_US
dc.subjectTuberculosisen_US
dc.subjectHIVen_US
dc.subjectWastingen_US
dc.subjectLean tissue mass indexen_US
dc.subjectFat mass indexen_US
dc.subjectBody mass indexen_US
dc.subjectGenderen_US
dc.titleWasting among Uganda men with pulmonary tuberculosis is associated with linear regain in lean tissue mass during and after treatment in contrast to women with wasting who regain fat tissue mass: prospective cohort studyen_US
dc.typeArticleen_US


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