Now showing items 1-6 of 6
Mammalian-wide interspersed repeat (MIR)-derived enhancers and the regulation of human gene expression
(BioMed Central, 2014)
Background: Mammalian-wide interspersed repeats (MIRs) are the most ancient family of transposable elements (TEs) in the human genome. The deep conservation of MIRs initially suggested the possibility that they had been ...
Effect of the transposable element environment of human genes on gene length and expression
(Oxford University Press, 2011-02-28)
Independent lines of investigation have documented effects of both transposable elements (TEs) and gene length (GL) on gene expression. However, TE gene fractions are highly correlated with GL, suggesting that they cannot ...
On the presence and role of human gene-body DNA methylation
(International Multidisciplinary Publishing Academy for Computational Technologies, 2012-05-09)
DNA methylation of promoter sequences is a repressive epigenetic mark that down-regulates gene expression. However, DNA methylation is more prevalent within gene-bodies than seen for promoters, and gene-body methylation ...
Transcriptional Activity, Chromosomal Distribution and Expression Effects of Transposable Elements in Coffea Genomes
(PLoS ONE (Public Library of Science), 2013-11-11)
Plant genomes are massively invaded by transposable elements (TEs), many of which are located near host genes and can thus impact gene expression. In flowering plants, TE expression can be activated (de-repressed) under ...
Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis
(American Society for Clinical Investigation, 2014)
In atherosclerosis, plaques preferentially develop in arterial regions of disturbed blood flow (d-flow), which alters endothelial gene expression and function. Here, we determined that d-flow regulates genome-wide DNA ...
Compound cis-regulatory elements with both boundary and enhancer sequences in the human genome
(Oxford University Press, 2013-10)
Motivation: It has been suggested that presumably distinct classes of genomic regulatory elements may actually share common sets of features and mechanisms. However, there has been no genome-wide assessment of the prevalence ...