Prevalence and risk factors of latent Tuberculosis among adolescents in rural Eastern Uganda
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Date
2015-09
Journal Title
Journal ISSN
Volume Title
Publisher
PubMed Central
Abstract
Background: Latent Tuberculosis treatment is a key tuberculosis control intervention. Adolescents are a high risk group that is not routinely treated in low income countries. Knowledge of latent Tuberculosis (TB) burden among adolescents may influence policy.
Objectives: We determined the prevalence and risk factors of latent TB infection among adolescents in rural Uganda.
Methods: We analyzed baseline data from a study that assessed the prevalence and incidence of Tuberculosis disease among adolescents. We extracted socio-demographics, medical assessment information, and tuberculin skin test results and estimated prevalence ratios (PR) of latent TB infection risk factors by binomial regression.
Results: The prevalence of latent TB was 16.1%, 95% CI (15.1 – 17.2). Significant risk factors were: a BCG scar, APR 1.29 (95% CI 1.12 – 1.48); male gender, APR 1.37 (95% CI 1.21 – 1.56); age 17 -18 years, APR 1.46 (95% CI 1.24 – 1.71) and 15-16 years, APR 1.25 (95% CI 1.07 – 1.46) compared to 12-14 years; being out of school, APR 1.31 (95% CI 1.05 – 1.62); and a known history of household TB contact in last 2 years, APR 1.91 (95% CI 1.55 – 2.35).
Conclusion: Targeted routine latent TB treatment among adolescents out of school may be crucial for TB disease control in low income countries.
Description
Keywords
Latent tuberculosis infection, Tuberculin skin testing, Tuberculosis infection in Adolescents - Uganda, Tuberculosis - Risk factors - Uganda
Citation
Mumpe-Mwanja D, Verver S, Yeka A, Etwom A, Waako J, Ssengooba W, Matovu JKB, Wanyenze RK, Musoke P, Mayanja-Kizza H. Prevalence and predictors of latent Tuberculosis among adolescents in rural Eastern Uganda. Afri Health Sci. 2015;15(3):851-60. doi: http://dx.doi.org/10.4314/ahs.v15i3.20